|
KMID : 1007520140230051667
|
|
Food Science and Biotechnology
2014 Volume.23 No. 5 p.1667 ~ p.1676
|
|
|
Effects of Nanopowdered Eggshell on Postmenopausal Osteoporosis: a Rat study
|
|
Mohammad Al Mijan
Lee Yun-Kyung
Kwak Hae-Soo
|
|
|
Abstract
|
|
|
|
The preventive effects of nanopowdered eggshell (NPES) on postmenopausal osteoporosis in ovariectomized rats was studied. Rats fed NPES and powdered eggshell (PES) exhibited 6.6 and 2.2% greater bone mineral densities (BMD) than ovariectomized (OVX) rats. NPES administration resulted in greater bone stiffness than PES. Investigation of the trabecular bone in NPES fed rats revealed a 12.4% higher bone volume (BV/TV), 7.5% higher trabecular number (Tb.N.), and 14.5% lower trabecular separation (Tb.Sp.), compared with OVX rats. Serum analysis demonstrated that NPES fed rats showed a significantly (p<0.05) higher (22.4%) osteocalcin level than OVX rats. Urine analyses in NPES fed rats revealed 43.7% lower deoxypyridinoline (DPD) and 87% lower Nteleopeptide levels of type I collagen (NTX) than in OVX rats. NPES attenuated the bone loss induced by ovariectomy in rats.
|
|
|
KEYWORD
|
|
|
eggshell, osteoporosis, nanopowder, ovariectomy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|